While on a journey of physical and spiritual healing, a brilliant neurosurgeon is drawn into the world of the mystic arts.

As his last assignment, a temporal agent is tasked to travel back in time and prevent a bomb attack in New York in 1975. The hunt, however, turns out to be beyond the bounds of possibility.

College student Ryan wakes up in his car on Tuesday, September 19. Returning to his dorm room, he walks in on his roommate Carter and Carter's girlfriend Tree. He resumes work on an experimental quantum reactor with fellow students Samar and Dre. After Bronson, the school dean, shuts down the project for triggering several power outages, Ryan is murdered by someone dressed as Babyface, and wakes up again on Tuesday the 19th. Tree explains her experience Happy Death Day#Plot, and she and Carter agree to help Ryan. They learn the reactor was responsible for creating the loop. The new Babyface tracks Ryan down, but Tree subdues and unmasks him to reveal another Ryan. The second Ryan warns that the original must die for the loop to close. Terrified, Ryan activates the reactor, releasing a powerful energy pulse that knocks everyone unconscious.